Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response againstToxoplasma gondiiInfection
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Open Access
- 1 January 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (1) , 617-621
- https://doi.org/10.1128/iai.73.1.617-621.2005
Abstract
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity againstToxoplasma gondii. IL-17R−/−mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.Keywords
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