The influence of the gonads on protein metabolism

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Abstract
Inj. of a lipoid extract of testes into normal adult [male] rabbits and into animals castrated less than 6 wks. previously increases urinary creatinine; in older castrates not yet showing a post-castration rise in creatinine it has no effect, but in long-standing castrates (6 mos. after castration) it induces a fall to pre-castration level. A quantitative relationship exists between dose and response. Injs. of saline suspensions of testes into normal animals and recent and long-standing castrates cause a fall in urinary creatinine. The admin. of testosterone and androsterone increases creatinine excretion in normal animals and the effect is prolonged if the hormones are injected in the form of esters. The inj. of extracts of adult [male] urine produces a biphasic effect[long dash]a fall below normal followed by a rise above normal on the next day and then a return to normal the day after; this is probably due to the presence of both androgens and oestrogens in the extract. Inj. of ant. pituitary extracts increases urinary creatinine in normal animals and in recent castrates but has no effect on the high creatinine output of long-standing castrates. The results suggest the presence of 2 different active principles in the testes; the response to injs. of testicular extracts depends on whether the ant. pituitary is normal or has undergone changes due to the castration.