HEMORRHAGIC DIATHESIS IN CARCINOMA OF THE STOMACH: A CASE REPORT

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Abstract
An acute bleeding diathesis with deficiencies of fibrinogen, prothrombin, labile and stabile factors, and platlets is reported in a patient with gastric carcinoma. Autopsy revealed metastatic disease in lymph nodes, bone, and lung, but only microscopically in one section of liver. Blood studies in 5 previous cases of this syndrome in gastric carcinoma are summarized. A decreased value for stabile prothrombin conversion factor found in this patient has not been reported previously. Although there is no definite evidence of the mechanism, a lytic enzyme(s) could best explain this hemorrhagic diathesis by its effect on fibrinogen, prothrombin, and the prothrombin conversion factors.