MORPHOLOGICAL-STUDY OF THE COMBINED EFFECT OF PURPURIN DERIVATIVES AND LIGHT ON TRANSPLANTABLE RAT BLADDER-TUMORS
- 15 January 1987
- journal article
- research article
- Vol. 47 (2) , 496-498
Abstract
Purpurin derivatives, a group of synthetic photosensitizers, were tested for their photodynaimc activity against transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced urothetial tumors growing in male Fischer 344 rats. Histological examination of tumors in animals treated with the purpurin derivative and red light (> 590 nm, 360 joules/cm2) revealed tumor cell necrosis 24 h after completion of therapy. Control tumors showed no histological change. Purpurins have a major absorption peak in the red region (>650 nm) of the visible spectrum, a region with good tissue penetration, and purpurins can be synthesized with a high degree of purity. This study demonstrate the potential of purpurin derivatives as photosensitizers for photodynamic cancer therapy.This publication has 8 references indexed in Scilit:
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