TOMOGRAPHIC SCINTIGRAPHY OF REGIONAL MYOCARDIAL PERFUSION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (8) , 764-769
Abstract
Estimation of the extent of regional ischemia by scintigraphic methods was hampered by the geometric constraints of 2-dimensional imaging. Myocardial perfusion scintigraphy was performed using the Fresnel zone-plate tomographic camera after the injection of 99mTc microspheres (20-40 .mu.) into a coronary artery. Coronary artery occlusion was performed in 6 dogs by embolization via a catheter guidewire system. Twenty millicuries of 99mTc microspheres were injected into the left main coronary artery of the 6 occluded and 3 unoccluded dogs. Scintigraphy was performed in multiple projections in the living animal. Optical reconstruction of the holographic image provided tomographic gamma images of the heart. Scintigraphy was performed with an Anger camera for comparison . The extent of the perfusion defect was measured by planimetry and expressed as a percentage of the ventricular area in that projection. The average of the right and left anterior oblique projections provided the most accurate estimate of the size of the perfusion defect (average error: 13.6%; range: 0-38.2%). Fresnel zone-plate imaging provided an accurate in vivo assessment of the extent of altered myocardial perfusion.

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