The Fate of Circulating Leukocytic Pyrogen in the Rabbit1,2

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Abstract
Leukocytic pyrogen (L.P.) is not actively inhibited by urine or by plasma nor is it excreted in an active form by the kidney. L.P. is promptly and almost completely cleared by the perfused liver within 20 min, suggesting that the liver is the organ primarily responsible for this action in the febrile rabbit.

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