STUDIES ON THE PHYSIOLOGY OF VIRULENCE OF PASTEURELLA TULARENSIS I

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Abstract
All virulent strains degrade citrulline to CO2, NH3 and ornithine; strains of very low to no virulence lack ureidase entirely. Active strains have enzymatic activity both as washed cells and assonic lysates, the activity independent of AMP-5, Mg++, and both phosphate and arsenate. Glutaminase and asparaginase are present in all strains irrespective of virulence but the avirulent strains contain less glutaminase/mg N than do the virulent strains. No differences were observed in asparaginase activities. Hence gross differences in degrees of virulence are associated with both qualitative and quantitative enzymatic differences.