Synthesis of a New Potent Anti-angiogenic Agent, 17.ALPHA.-Acetoxy-9.ALPHA.-fluoro-6.ALPHA.-methylprogesterone (9.ALPHA.-Fluoromedroxyprogesterone acetate(FMPA)).
- 1 January 1997
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 45 (2) , 421-423
- https://doi.org/10.1248/cpb.45.421
Abstract
A new anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedoroxyprogesterone acetate [FMPA, 9] was synthetized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger anti-angiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.Keywords
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