Structure of the Vesicular Stomatitis Virus Nucleoprotein-RNA Complex
Top Cited Papers
- 21 July 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 313 (5785) , 357-360
- https://doi.org/10.1126/science.1126953
Abstract
Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.Keywords
This publication has 17 references indexed in Scilit:
- Resolution improvement of X-ray diffraction data of crystals of a vesicular stomatitis virus nucleocapsid protein oligomer complexed with RNAActa Crystallographica Section D-Biological Crystallography, 2006
- Visualizing the RNA Molecule in the Bacterially Expressed Vesicular Stomatitis Virus Nucleoprotein-RNA ComplexStructure, 2004
- Three‐dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particleEMBO Reports, 2001
- Structure of Recombinant Rabies Virus Nucleoprotein-RNA Complex and Identification of the Phosphoprotein Binding siteJournal of Virology, 2001
- [25] RibbonsPublished by Elsevier ,1997
- Vesicular Stomatitis Virus RNA Replication: a Role for the NS ProteinJournal of General Virology, 1989
- Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.Proceedings of the National Academy of Sciences, 1981
- The fine structure of vesicular stomatitis virusVirology, 1968
- Comparative sedimentation coefficients of RNA extracted from plaque-forming and defective particles of vesicular stomatitis virusJournal of Molecular Biology, 1966
- The development and structure of vesicular stomatitis virusVirology, 1962