The Key–Lock Theory and the Induced Fit Theory
- 3 January 1995
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 33 (23-24) , 2375-2378
- https://doi.org/10.1002/anie.199423751
Abstract
As a glove changes shape when a hand slips into it, so an enzyme changes its conformation on binding a ligand. This theory of induced fit extends the lock‐and‐key principle that Emil Fischer proposed exactly 100 years ago. The new theory proposed by D. E. Koshland, Jr. in 1958 allows one to explain regulation and cooperative effects, and adds some new specificity principles as well.Keywords
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