The nucleotide sequence of the yeastPHO5gene: a putative precursor of repressible acid phosphatase contains a signal peptide
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (6) , 1657-1672
- https://doi.org/10.1093/nar/11.6.1657
Abstract
The nucleotide sequence of the PH05 gene of the yeast, Saccharomyces cerevisiae, which encodes repressible acid phosphatase (APase) was determined. Comparison of N‐terminal amino acid sequence deduced from the nucleotide sequence with that of the purified repressible APase revealed the existence of a putative signal peptide in the precursor protein. The signal peptide was shown to contain 17 amino acid residues and its structural features were quite similar to those of higher eukaryotic and prokaryotlc signal peptides. The nucleotide sequence of 5′ and 3′ noncoding flanking regions of the PH05 gene are also discussed.Keywords
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