Apolipoprotein E Genotype and its Effect on Duration and Severity of Early and Late Onset Alzheimer's Disease
- 1 October 1995
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 167 (4) , 533-536
- https://doi.org/10.1192/bjp.167.4.533
Abstract
Background: The apolipoprotein E (ApoE) ∊4 allele is associated with an increased risk of senile and probably presenile Alzheimer's disease. It is not yet clear whether the ∊4 allele also influences the duration/rate of progress of illness and the severity of the dementia.Method: We have retrospectively examined a series of ApoE genotyped presenile and senile autopsy cases of Alzheimer's disease (AD) for length of illness and severity of pathology.Results: We find no evidence that ApoE genotype affects the rate of progress of AD, but the degree of pathology at death may be increased.Conclusion: It appears that the rate of progress of AD as a whole is independent of the ApoE genotype.Keywords
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