THE EFFECT OF PIPERAZINE ON SUCCINATE PRODUCTION BY ASCARIS LUMBRICOIDES
Open Access
- 1 December 1959
- journal article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (4) , 497-500
- https://doi.org/10.1111/j.1476-5381.1959.tb00955.x
Abstract
Piperazine reduced the production of succinate by Ascaris lumbricoides. This effect was reversible. There was a close parallelism between the concentrations of piperazine which paralysed the worm and those which inhibited the formation of succinate. Piperazine did not affect the incorporation of [2‐14C]lactate into succinate by strips of Ascaris muscle. It was concluded that production of succinate supplies energy for the contraction of Ascaris muscle.Keywords
This publication has 12 references indexed in Scilit:
- The Mechanism of Formation of Succinate and Propionate by Ascaris lumbricoides MuscleJournal of Biological Chemistry, 1959
- Investigations on the Action of Piperazine on Ascaris LumbricoidesThe American Journal of Tropical Medicine and Hygiene, 1957
- Anthelmintics.1957
- THE OXIDATIVE DECARBOXYLATION OF MALATE BY ASCARIS LUMBRICOIDESJournal of Biological Chemistry, 1957
- Identification of succinic acid as a constituent of the perienteric fluid of Ascaris lumbricoidesExperimental Parasitology, 1956
- TREATMENT OF ENTEROBIASIS AND ASCARIASIS WITH PIPERAZINEJAMA, 1956
- Dissociation of the succinoxidase systems of Ascaris lumbricoides and of rat kidneyBiochimica et Biophysica Acta, 1955
- The Treatment of Cases of Ascariasis with Piperazine CitrateThe American Journal of Tropical Medicine and Hygiene, 1955
- CYTOCHROME c, CYTOCHROME OXIDASE, AND SUCCINOXIDASE ACTIVITIES OF HELMINTHSJournal of Biological Chemistry, 1952
- Production of Steam Volatile Acids by Bacteria-Free Ascaris LumbricoidesThe Journal of Infectious Diseases, 1950