NMR images by the multiple sensitive point method: application to larger biological systems

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Abstract
Image formation by NMR was initially restricted to objects of order 1 cm in size in order to be accommodated within the magnet gap of conventional NMR sprectrometers. With a view to applying the method to problems in medicine and biology an NMR imaging system was developed capable of examining objects of order 10 cm in size, and in this note the 1st examples of images obtained with this instrument are reported. Features of this system are its successful exploitation of a new fast multisensitive point method, the use of a steady-state free precession NMR Mode of operation to optimize sensitivity and the generation of truly 3-dimensional images. With the present instrument investigations of animals and human limbs are possible with a view to assessment of prospects of the usefulness of NMR imaging in medicine and other fields.