Peroxisome proliferators show tumor‐promoting but no direct transforming activity in vitro
- 15 January 1986
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 37 (1) , 97-100
- https://doi.org/10.1002/ijc.2910370116
Abstract
The chemically unrelated hypolipidemic drugs, tiadenol, niadenate, and clofibrate4 have been tested for carcinogenic and tumor-promoting potential in the C3H/10T1/2 C18 cell test system. None of these chemicals were carcinogenic, while both niadenate and clofibrate were active tumor promoters at micromolar concentrations. All 3 drugs induced the differentiation of C3H/10T1/2 C18 cells to adipocytes. This latter finding confirms previously observed effects of the tumor promoter TPA.This publication has 27 references indexed in Scilit:
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