Carcinogenic Effect of di- n -Propylnitrosamine in Syrian Golden Hamsters 2
- 1 September 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (3) , 1019-1027
- https://doi.org/10.1093/jnci/51.3.1019
Abstract
Weekly subcutaneous injections of 3.75–60 mg/kg body weight di-n-propylnitrosamine (DPN) caused papillary tumors and carcinomas of the respiratory system in Syrian golden hamsters. The trachea was the main target organ, then the nasal cavities, lungs, stem bronchi, and larynx. The number of tumors in the trachea was largest in the upper segment, smaller in the middle segment, and smallest in the lower segment. The low doses of DPN resulted in mostly benign tumors of epidermoid, mucoepidermoid, and polypous type and a few squamous cell carcinomas in the anterior region of the nasal cavity, whereas the highest doses induced, in addition, carcinomas in the posterior region of the nasoturbinals and ethmoturbinals in 75% of the animals. Results demonstrate that the carcinogenic response of the Syrian golden hamster to DPN follows distinct patterns in the different segments of the respiratory tract.Keywords
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