Cytotoxicities of autoxidized polyunsturated fatty acids toward cultured human umbilical vein endothelial cells.

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Abstract
Cytotoxicities of autoxidized polyunsaturated fatty acids toward human umbilical vein endothelial cells were examined. Autoxidized linoleic acid is more toxic than linoleic, autoxidized linolenic, or autoxidized arachidonic acid. Autoxidized linolenic acid is less toxic than linolenic acid. Autoxidized arachidonic acid is as toxic as linolenic or arachidonic acid. It was found that major toxic components in autoxidized linoleic acid are linoleic acid hydroperoxides, and hat a major component in autoxidized arachidonic acid is (E)-4-hydroxy-2-nonenal.