Myotube Assembly on Nanofibrous and Micropatterned Polymers
Top Cited Papers
- 16 February 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 6 (3) , 537-542
- https://doi.org/10.1021/nl060060o
Abstract
Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts. We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation. This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.Keywords
This publication has 18 references indexed in Scilit:
- Electrospun fine-textured scaffolds for heart tissue constructsBiomaterials, 2005
- A microfluidic culture platform for CNS axonal injury, regeneration and transportNature Methods, 2005
- Continuous Electrospinning of Aligned Polymer Nanofibers onto a Wire Drum CollectorNano Letters, 2004
- Micropatterned Environments in Cell BiologyAdvanced Materials, 2004
- Structure and Morphology Changes during in Vitro Degradation of Electrospun Poly(glycolide-co-lactide) Nanofiber MembraneBiomacromolecules, 2003
- Micropatterning tractional forces in living cellsCell Motility, 2002
- Soft Lithography in Biology and BiochemistryAnnual Review of Biomedical Engineering, 2001
- Microengineering of Cellular InteractionsAnnual Review of Biomedical Engineering, 2000
- Lamina-Specific Connectivity in the Brain: Regulation by N-Cadherin, Neurotrophins, and GlycoconjugatesScience, 1997
- Skeletal myoblast transplantation for repair of myocardial necrosis.Journal of Clinical Investigation, 1996