Effect of Anti-estrogenic Action of Clomiphene During the Menstrual Cycle: Evidence for a Change in the Feedback Sensitivity

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Abstract
The anti-estrogenic effect of clomiphene (Clomid) was evaluated during different phases of the ovulatory cycle. Clomid induced a significant increase in circulating LH when administered during the follicular phase, but not during luteal phase of the cycle. A difference in the quantitative rise of LH which was greater during the late than during the early follicular phase of the cycle and the reverse for FSH was found. This disparity between LH and FSH responses may be related to the preferential inhibition of FSH as compared to LH by E2 which was present in increasing amounts during the late follicular phase. The increased gonadotropin levels in response to Clomid treatment are composed of integrations of an enhanced pulsatile discharge as revealed by frequent blood sampling studies. These data suggest that a decrease in the negative feedback effect of estradiol exists for LH but not FSH during the course of the follicular phase.

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