Pituitary and Adrenal Influences on Insulin-I131 Degradation

Abstract
Insulin-I131 degradation in rats was profoundly diminished after hypophysectomy. Adrenalectomized rats and rats treated with hydrocortisone, and/or growth hormone showed little alteration in insulin-I131 degradation, and no evidence was obtained to indicate that alterations of carbohydrate metabolism, produced by such conditions, are related to altered insulin degradation.