Sperm penetration through cumulus mass and zona pellucida
- 1 January 2008
- journal article
- research article
- Published by UPV/EHU Press in The International Journal of Developmental Biology
- Vol. 52 (5-6) , 677-682
- https://doi.org/10.1387/ijdb.072528ek
Abstract
Mammalian fertilization requires sperm to penetrate the cumulus mass and egg zona pellucida prior to fusion with the egg. Although sperm penetration through these physical barriers is essential, the molecular mechanism has not yet been completely elucidated. In addition to sperm motility, hyaluronan-hydrolyzing and proteolytic enzymes of sperm have been suggested to participate in the penetration events. Here we focus on the functional roles of hyaluronidase and protease in sperm passage through the cumulus mass and zona pellucida.Keywords
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