Relation Between Levels of Circulating Ovarian Steroids and Pituitary Gonadotropin Content During the Menstrual Cycle of the Rhesus Monkey1

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Abstract
Anterior pituitary glands were removed from 27 intact cycling thesus monkeys sacrificed in the early (day 2), mid (days 6-9) and late (days 11-12) follicular phase, and in the early and late luteal phase (3-5 and 10-15 days after the midcycle luteinizing hormone (LH) surge). Assignment of cycle stage was confirmed by the pattern of circulating steroid and gonadotropin levels seen in the blood samples taken daily throughout the cycle. The anterior pituitary glands were weighed, stored at -30.degree. C and assayed for LH and FSH content by specific radioimmunoassays. Serum estradiol levels and pituitary LH and FSH contents rose simultaneously during the follicular phase. After the preovulatory gonadotropin surge, pituitary LH content was low and invariant. Pituitary FSH content reached a nadir in the early luteal phase and tended to rise in the late luteal phase. Multiple correlation analyses revealed that there is a positive correlation between rising levels of estradiol in the circulation and pituitary LH (p = 0.003) and FSH (p = 0.017) content, and that there is a significant negative correlation between circulating progesterone levels and pituitary FSH content (p = 0.002). Pituitary LH content is less strongly related to circulating progestrone levels. There was no significant difference in the wet weights of the anterior pituitary glands during the 5 phases of the menstrual cycle studied.

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