Decreased Insulin Receptors But Normal Glucose Metabolism in Duchenne Muscular Dystrophy
- 16 April 1982
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4543) , 311-313
- https://doi.org/10.1126/science.7063889
Abstract
Compared to matched controls, 17 patients with Duchenne muscular dystrophy showed decreased insulin binding to monocytes due to decreased receptor concentration. These patients showed no signs of altered glucose metabolism and retrospective analysis of the clinical records of a further 56 such patients revealed no modification in carbohydrate metabolism. These data suggest that reduced insulin receptor number does not produce overt modifications of glucose metabolism in Duchenne muscular dystrophy.Keywords
This publication has 12 references indexed in Scilit:
- Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic SubjectsDiabetes, 1981
- DEMONSTRATION OF A PRIMARY (? GENETIC) DEFECT IN INSULIN RECEPTORS IN FIBROBLASTS FROM A PATIENT WITH THE SYNDROME OF INSULIN RESISTANCE AND ACANTHOSIS NIGRICANS TYPE AJournal of Clinical Endocrinology & Metabolism, 1980
- Differences in Insulin Receptors between Men and Menstruating Women and Influence of Sex Hormones on Insulin Binding during the Menstrual Cycle*Journal of Clinical Endocrinology & Metabolism, 1980
- INSULIN RECEPTORS DURING THE MENSTRUAL CYCLE IN NORMAL WOMENJournal of Clinical Endocrinology & Metabolism, 1978
- Duchenne dystrophy: Focal alterations in the distribution of concanavalin a binding sites at the muscle cell surfaceAnnals of Neurology, 1978
- Erythrocyte Lipids in Heterozygous Carriers of Duchenne Muscular DystrophyScience, 1977
- Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin ResistanceScience, 1975
- Time course of insulin-receptor binding and insulin-induced lipogenesis in isolated rat fat cells.Journal of Biological Chemistry, 1975
- Association of actin and myosin with secretory granule membranesNature, 1975
- Muscle membrane protein kinase in myotonic muscular dystrophyNature, 1974