Cell morphology, proliferation and collagen synthesis of human fibroblasts cultured on sepiolite-collagen complexes

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Abstract
The growth and morphology as well as collagen biosynthesis of human fibroblasts obtained and cultured on sepiolite–collagen complexes have been studied. No differences on cell morphology and growth properties nor collagen synthesis were observed when compared with standard culture substrates. The type I/type III ratio of biosynthesized collagen by fibroblasts cultured on sepiolite–collagen complexes was about 5–6 with no difference when compared to control conditions. This normal behavior was also observed for the type I/type III procollagens. According to these studies the sepiolite–collagen complexes do not modify the studied features of the fibroblasts.