Cefotetan activity against Gram-negative aerobes and anaerobes

Abstract
The activity of cefotetan has been determined against strains of bacteroides, Haemophilus influenzae and klebsiella. The activity against bacteroides was lower than that of cefoxitin and moxalactam. The activity against multi-resistant klebsiella was very high, most strains requiring a concentration of 0.06 mg/l for inhibition. The stability to various β-lactamases was demonstrated by testing the compound against β-lactamase-producing H. influenzae and Enterobacteriaceae.

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