Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes
Top Cited Papers
- 29 August 2016
- journal article
- Published by Springer Nature in Nature Biotechnology
- Vol. 34 (10) , 1037-1045
- https://doi.org/10.1038/nbt.3662
Abstract
Detection of more than 1,000 different T-cell specificities in parallel facilitates identification of cancer and autoimmune antigens.Keywords
This publication has 52 references indexed in Scilit:
- Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterizationNature Biotechnology, 2013
- MHC Multimer-Guided and Cell Culture-Independent Isolation of Functional T Cell Receptors from Single Cells Facilitates TCR Identification for ImmunotherapyPLOS ONE, 2013
- Conditional ligands for Asian HLA variants facilitate the definition of CD8+T‐cell responses in acute and chronic viral diseasesEuropean Journal of Immunology, 2012
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion SequencingNew England Journal of Medicine, 2012
- Fast gapped-read alignment with Bowtie 2Nature Methods, 2012
- Simultaneous detection of many T-cell specificities using combinatorial tetramer stainingNature Methods, 2009
- Design of 240,000 orthogonal 25mer DNA barcode probesProceedings of the National Academy of Sciences, 2009
- Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7Proceedings of the National Academy of Sciences, 2008
- Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigenProceedings of the National Academy of Sciences, 2008
- T-cell antigen receptor genes and T-cell recognitionNature, 1988