Nephrotoxic Action of Spermine
- 1 July 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 80 (3) , 432-434
- https://doi.org/10.3181/00379727-80-19647
Abstract
Spermine admd. parenterally was highly active in producing renal injury. Intraperit. injns. of 30-60 mg./kg. produced death from renal failure within 7 days in mice, rats and rabbits. The renal lesions consisted of degenerative changes in the proximal convoluted tubules, and the presence of numerous casts in the tubules. This nephrotoxic acition was not observed with spermidine, putrescine, or cadaverine.Keywords
This publication has 2 references indexed in Scilit:
- THE EFFECT OF SPERMINE ON TUBERCLE BACILLIThe Journal of Experimental Medicine, 1952
- PUTRESCINE AS A GROWTH FACTOR FOR HEMOPHILUS PARAINFLUENZAEJournal of Biological Chemistry, 1948