Comparative Function of Centrifugal Apheresis Devices

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Abstract
The function of four apheresis devices has been evaluated to obtain comparative data on performance and safety. Granulocyte yields were highest with the CS‐3000 with 1.7 times 1010 cells, but this preparation also contained 4.5 times 1011 platelets; plateletpheresis gave ranges of 3.4 times 1011 to 4.5 times 1011 cells. The amount of blood processed to obtain these yields varied greatly, ranging from 2.4 to 7 liters. Studies done on the donor return line showed no significant effects of the process. Comparative results on the efficacy of plasma exchange showed relatively little red cell contamination with any of these devices, but significant (6.9 times 1010) platelet removal in the Fenwal bag.