Electrospray Mass Spectrometry for Measurement of Glycohemoglobin

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Abstract
With the publication of the results of the landmark 9-year Diabetes Control and Complications Trial (DCCT), the importance of Hb A1c/glycohemoglobin testing in diabetes was firmly established. The DCCT showed, at least in patients with insulin-dependent diabetes mellitus, that the risk for development and progression of the chronic complications of diabetes is closely related to the degree of metabolic control as measured by glycohemoglobin determinations (1). Generally, the same is believed to be true for patients with non-insulin-dependent diabetes mellitus, although the results of the UK Prospective Study must be awaited (2)(3).