Effect of Vaccination with Refined Components of the Organism on Infection of Mice with Mycobacterium leprae
Open Access
- 1 March 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (3) , 1596-1598
- https://doi.org/10.1128/iai.71.3.1596-1598.2003
Abstract
Only native products of Mycobacterium leprae , whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton—the mycolyl-arabinogalactan-peptidoglycan complex—devoid of proteins is not protective.Keywords
This publication has 22 references indexed in Scilit:
- Vaccination with Plasmid DNA Encoding TSA/LmSTI1 Leishmanial Fusion Proteins Confers Protection againstLeishmania majorInfection in Susceptible BALB/c MiceInfection and Immunity, 2002
- Evaluation of DPPD, a single recombinant Mycobacterium tuberculosis protein as an alternative antigen for the Mantoux testTuberculosis, 2001
- Global leprosy situation, September 1999.1999
- Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in MalawiThe Lancet, 1996
- CD1-Restricted T Cell Recognition of Microbial Lipoglycan AntigensScience, 1995
- THE ENVELOPE OF MYCOBACTERIAAnnual Review of Biochemistry, 1995
- Recognition of a lipid antigen by CD1-restricted αβ+ T cellsNature, 1994
- Immunoprophylactic trial with combined Mycobacterium Leprae/BCG vaccine against leprosy: preliminary resultsThe Lancet, 1992
- Cell Walls from Mycobacterium tuberculosis (BCG) as Vaccine Against Mycobacterium leprae Infections in MiceExperimental Biology and Medicine, 1968
- THE EXPERIMENTAL DISEASE THAT FOLLOWS THE INJECTION OF HUMAN LEPROSY BACILLI INTO FOOT-PADS OF MICEThe Journal of Experimental Medicine, 1960