Serotonergic influence on the growth hormone response to clonidine in rat
- 1 March 1987
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 69 (1-2) , 105-114
- https://doi.org/10.1007/bf01244101
Abstract
Administration of the alpha2-adrenoceptor agonist clonidine induces growth hormone (GH) release in rat and man. In the present study it is shown that the GH response to clonidine is weaker in rats exposed to depletion of both noradrenaline and serotonin (by means of reserpine or the combined treatment of FLA-63 and PCPA) than in animals exposed to noradrenaline depletion (by means of FLA-63) only. The possibility that an impaired serotonergic neurotransmission contributes to the blunted GH responses to clonidine observed in patients suffering from endogenous depression is discussed.This publication has 37 references indexed in Scilit:
- Effects of Neonatal Treatment with Monosodium Glutamate on Growth Hormone Release Induced by Clonidine and Prostaglandin E1 in Conscious Male RatsNeuroendocrinology, 1983
- Ectopic Growth Hormone-Releasing Factor Stimulates Growth Hormone Secretion in the Urethane-Anesthetized Rat in vivoNeuroendocrinology, 1983
- Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretionBiochemical and Biophysical Research Communications, 1982
- Growth Hormone and other Responses to Clonidine in Patients with Endogenous DepressionThe British Journal of Psychiatry, 1981
- Central Catecholamine Depletion: Effects on Physiological Growth Hormone and Prolactin SecretionNeuroendocrinology, 1981
- MONOAMINERGIC REGULATION OF GROWTH HORMONE IN THE RATJournal of Endocrinology, 1980
- Effects of electroconvulsive treatment on growth hormone secretion induced by monoamine receptor agonists in reserpine-pretreated ratsPsychoneuroendocrinology, 1980
- Effects of apomorphine and clonidine on rat plasma growth hormone after pretreatment with reserpine and electroconvulsive shocksBrain Research, 1977
- Physiological role of somatostatin in the control of growth hormone and thyrotropin secretionBiochemical and Biophysical Research Communications, 1976
- Effects of reserpine and a tyrosine hydroxylase inhibitor on the monoamine levels in different regions of the rat central nervous systemEuropean Journal of Pharmacology, 1967