THE GROWTH AND HISTOLOGIC CHANGES OF HUMAN THYROIDAL TUMORS TRANSPLANTED INTO THE ANTERIOR CHAMBER OF THE EYES OF GUINEA PIGS*†

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Abstract
A variety of human thyroidal tumors have been transplanted into the anterior chamber of the guinea pig''s eye. Numerous malignant lesions have survived and grown. Human thyroidal tissue, serving as controls, and benign lesions tended to be absorbed after short intervals of time; however, the normal thyroidal tissue had been found to survive for as long as 90 days in intact animals. Two primitive fetal adenomas were classified as benign on the basis of morphologic criteria; however, their behavior after transplantation suggested that a diagnosis of malignancy should have been made. The usefulness of the method as a means of distinguishing between benign and malignant lesions of the thyroid requires further investigation. Following the transplantation of malignant lesions a tendency towards differentiation has occurred. One very anaplastic tumor has been retransplanted through 9 generations in a large number of animals, during which time many different histologic patterns of carcinoma of the thyroid have evolved.

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