THE EFFECT OF A HYPOTHALAMIC EXTRACT ON THE PLASMA LUTEJNIZING HORMONE (LH) ACTIVITY OF THE ESTROGENIZED, OVARIECTOMIZED RAT1
- 1 June 1961
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 68 (6) , 1071-1073
- https://doi.org/10.1210/endo-68-6-1071
Abstract
The LH activity of rat plasma was estimated by the ovarian ascorbic acid depletion method. Significant LH activity was found in plasma from rats which had been ovariectomized for 1-4 months. A single subcutaneous injection of 1.0 μg of estradiol benzoate produced a marked decrease in this activity on assay 3 days later. The LH activity in plasma of such estrogen-treated, ovariectomized rats was significantly elevated within 10 minutes after the intravenous injection of an acidic extract of rat stalk-median eminence tissue, whereas injection of extract from cerebral cortex was without significant effect. It is suggested that stalk-median eminence tissue contains a specific LH-releasing factor.Keywords
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