Apomorphine can sustain the long-duration response to l -DOPA in fluctuating PD
- 11 January 2000
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 54 (1) , 247
- https://doi.org/10.1212/wnl.54.1.247
Abstract
Article abstract The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long-duration response (LDR) in seven subjects with fluctuating PD in whom l-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects “on” during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.Keywords
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