Adrenergic receptor agonists

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Abstract
Two hydroxy-substituted benzofuranylethanolamines (9 and 10), analogs of adrenoceptor-active aryloxypropanolamines, were prepared and their .beta.-adrenoceptor activity was examined [in the cat]. Compound 9 was a .beta.1-selective adrenergic agonist with high intrinsic activity. Due to the rigidity of the benzofuranyl moiety of 9, its functional groups cannot be brought into the same spatial positions as those of a phenylethanolamine-type agonist like isoprenaline. This could indicate that adrenergic agonists of the aryloxypropanolamine type and of the phenylethanolamine type are differently bound to the receptor when eliciting the effect.