Resistance to Antiviral Drugs: The End of Innocence

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Abstract
Until recently, the problem of resistance to antiviral drugs has been more potential than real. Although individual reports of resistant viruses have appeared, such isolates have been rare and usually of low virulence. The articles by Erlich et al.1 and Erice et al.2 in this issue of the Journal, as well as reports published elsewhere,3 , 4 indicate that the situation has changed dramatically. Progressive disease due to acyclovir-resistant herpes simplex virus and to ganciclovir-resistant cytomegalovirus in patients with the acquired immunodeficiency syndrome (AIDS) or who are otherwise immunocompromised is now a reality with important ramifications.Resistance of herpes simplex virus . . .