Immunization against Lyme Disease — An Important First Step

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Abstract
Lyme disease is an inflammatory disorder that can involve the skin and the musculoskeletal, neurologic, and cardiovascular systems.1 The etiologic agent, Borrelia burgdorferi, was isolated from tick vectors in 19822 and subsequently from patients in 1983.3,4 Lyme disease is the most common vector-borne disease in the United States, with 16,461 cases reported to the Centers for Disease Control and Prevention in 1996.5 Although cases have been reported in 45 states, they are clustered in the mid-Atlantic, Northeast, and North Central regions. The prevalence of Lyme disease is affected by the proportions of infected small-mammal reservoirs, tick vectors, and their . . .