REVERSIBLE PREVENTION OF PLATELET ACTIVATION BY (E,Z)-4,5,9-TRITHIADODECA-1,6,11-TRIENE 9-OXIDE (AJOENE) IN DOGS UNDER EXTRACORPOREAL-CIRCULATION
- 1 July 1988
- journal article
- research article
- Vol. 38-2 (7) , 901-904
Abstract
Ajoene ((E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide), an organosulfur compound derived from garlic inhibits platelet activation induced ex vivo by all known agonists. The effect of ajoene on the thrombocytopenia associated with the circulatin of blood through extracorporeal devices such as dialyzers or oxygenators was studied under the following conditions: Ex vivo using fresh, heparinized human blood, circulating through a dialyzer or oxygenator, and in vivo, in dogs subjected to extracorporeal circulation. In both experimental conditions ajoene proved very efficacious in preventing platelet loss (60-65% loss in controls vs. 15-20% loss in the presence of ajoene, p < 0.01). Moreover, recuperation of platelet function was achieved after 3-4 h in the in vivo experiments.This publication has 9 references indexed in Scilit:
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