ONLY B LYMPHOCYTES INDUCE ACTIVE ENHANCEMENT OF RAT CARDIAC ALLOGRAFTS

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Abstract
LEW rats were immunized 7 days before (LEW .times. BN)F1 heart transplantation with 107 BN donor cells, purified erythrocytes (RBC), peripheral blood (PBL), splenic, nylon-wool-adherent (B[bone marrow-derived cell]-enriched) or nylon-wool-nonadherent (T[thymus-derived cell]-enriched) lymphocytes. Allograft rejection was only significantly enhanced in animals pretreated with lymphocyte populations containing surface immunoglobulin (SIgG)-positive cells (PBL, splenic or B-enriched lymphocytes). Recipients immunized with RBC or T-enriched lymphocytes containing few, if any, SIgG-bearing B lymphocytes, showed no significant graft prolongation.