Pharmacological Studies on Saiko-Prescriptions. IV. Effect of Shosaiko-to on Swelling of Rat Hind Paws Induced by Carrageenin

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Abstract
The effects of Shosaiko-to and its constituent crude drugs on the inflammatory responses were investigated in rats. The i.p. administration of Shosaiko-to produced a dose-dependent inhibitory effect on the carrageenin-induced paw edema in rats. The suppression of the carrageenin-induced paw edema by Shosaiko-to decreased significantly in adrenalectomized rats. The elevations of serum and adrenal corticosterone levels were observed in rats treated with Shosaiko-to. Bupleuri Radix, Scutellariae Radix, Zingiberis Rhizoma and Ginseng Radix 100 mg/kg i.p. suppressed significantly carrageenin-induced paw edema, but Glycyrrhizae Radix, Zizyphi Inermi Fructus and Pinelliae Tuber did not. The active principles of Shosaiko-to producing antiinflammatory effects were absorbed on Amberlite XAD-2 and eluted with ethanol. Apparently Shosaiko-to suppressed the carrageenin paw edema and the antiinflammatory action was partly due to an increase in adrenal function.

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