Antibiotics from Basidiomycetes. XIII The alliacols A and B from Maramius alliaceus (JACQ ex Fr.) Fr.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (10) , 1271-1277
- https://doi.org/10.7164/antibiotics.34.1271
Abstract
Two antimicrobial and cytotoxic metabolites were isolated from fermentation broth of M. alliaceus. The structures of the 2 crystalline antibiotics, alliacols A (6) and B (1) were elucidated by spectroscopic methods and chemical correlation with alliacolide (3). The alliacols show weak antibacterial and antifungal activity. Both antibiotics strongly inhibit DNA synthesis in cells of the ascitic form of [mouse] Ehrlich carcinoma at concentrations of 2-5 .mu.g/ml. Alliacols A and B react with cysteine to form adducts with strongly reduced biological activities.This publication has 1 reference indexed in Scilit:
- Tumor inhibitors having potential for interaction with mercapto enzymes and/or coenzymesBioorganic Chemistry, 1977