Mitochondria and ageing
- 1 November 2000
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Clinical Nutrition and Metabolic Care
- Vol. 3 (6) , 473-478
- https://doi.org/10.1097/00075197-200011000-00009
Abstract
Mitochondria have long been proposed as a perpetrator of aging. We review here the accumulating evidence for chronological alterations in the mitochondrion and discuss how these changes may cause cellular dysfunction and death. We conclude that although the evidence for aging changes in the level of oxidative stress, DNA mutations and biochemical deficiencies in mitochondria are convincing, there is little experimental evidence to link these changes directly with the cellular pathology of aging. Promising avenues for addressing this problem include the investigation of established mitochondrial DNA disorders and the development of animal models with mitochondrial defects.Keywords
This publication has 45 references indexed in Scilit:
- Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogasterPublished by Elsevier ,2003
- Neuropathological and Histochemical Changes in a Multiple Mitochondrial DNA Deletion DisorderJournal of Neuropathology and Experimental Neurology, 2000
- Mitochondrial DNA and diseaseThe Lancet, 1999
- Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.Proceedings of the National Academy of Sciences, 1996
- Focal cytochrome c oxidase deficiency in the brain and dorsal root ganglia in a case with mitochondrial encephalomyopathy (tRNAIle 4269 mutation): histochemical, immunohistochemical, and ultrastructural studyJournal of the Neurological Sciences, 1995
- Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathyHuman Molecular Genetics, 1994
- Expression of supreoxide dismutase and catalase in rat brain as a function of ageMechanisms of Ageing and Development, 1991
- Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect speciesFree Radical Biology & Medicine, 1990
- Age-dependent structural changes in the myocardium of rats. A quantitative light- and electron-microscopic study on the right and left chamber wallMechanisms of Ageing and Development, 1984
- The Biologic Clock: The Mitochondria?Journal of the American Geriatrics Society, 1972