Lysosomal trafficking functions of mucolipin-1 in murine macrophages
Open Access
- 21 December 2007
- journal article
- Published by Springer Nature in BMC Cell Biology
- Vol. 8 (1) , 54
- https://doi.org/10.1186/1471-2121-8-54
Abstract
Mucolipidosis Type IV is currently characterized as a lysosomal storage disorder with defects that include corneal clouding, achlorhydria and psychomotor retardation. MCOLN1, the gene responsible for this disease, encodes the protein mucolipin-1 that belongs to the "Transient Receptor Potential" family of proteins and has been shown to function as a non-selective cation channel whose activity is modulated by pH. Two cell biological defects that have been described in MLIV fibroblasts are a hyperacidification of lysosomes and a delay in the exit of lipids from lysosomes.Keywords
This publication has 55 references indexed in Scilit:
- TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytesEuropean Journal of Cell Biology, 2006
- Basis of lethality in C. elegans lacking CUP-5, the Mucolipidosis Type IV orthologueDevelopmental Biology, 2006
- Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent proteinNature Biotechnology, 2004
- Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IVBiochemical and Biophysical Research Communications, 2004
- Phosphatidic acid positively regulates LPS-induced differentiation of RAW264.7 murine macrophage cell line into dendritic-like cellsBiochemical and Biophysical Research Communications, 2004
- Overexpression of wild‐type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organizationFEBS Letters, 2004
- Evidence for lipopolysaccharideinduced differentiation of RAW264.7 murine macrophage cell line into dendritic like cellsJournal of Biosciences, 2003
- Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membraneNature, 2002
- T-cell engagement of dendritic cells rapidly rearranges MHC class II transportNature, 2002
- Congenital corneal clouding with abnormal systemic storage bodies: A new variant of mucolipidosisThe Journal of Pediatrics, 1974