Development of circadian rhythmicity and light responsiveness in the rat suprachiasmatic nucleus: a study using the 2-deoxy[1-14C]glucose method.
- 1 February 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (2) , 1204-1208
- https://doi.org/10.1073/pnas.77.2.1204
Abstract
The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to play a critical role in circadian rhythm generation and entrainment to the light/dark cycle. In adult rats, the SCN shows a circadian rhythm in metabolic activity level as indicated by 2-deoxy[1-14C]glucose uptake. The development of this rhythm was investigated. No diurnal difference in uptake was evident in fetal rats 1-2 days before birth. A significant diurnal difference in SCN 2-deoxyglucose uptake was present on postnatal day 1, even in rats kept in constant darkness. By day 1, exposure to light at night increased the SCN metabolic levels. According to previous studies, on day 1 the SCN is poorly developed and contains few synapses. At this time the retinohypothalamic tract has not yet developed. Progressive functional maturation of the SCN was found through day 21, when the rhythm and light responsiveness resembled those of adult rats.This publication has 33 references indexed in Scilit:
- Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the ratPublished by Elsevier ,2003
- Suprachiasmatic Nucleus: Use of 14 C-Labeled Deoxyglucose Uptake as a Functional MarkerScience, 1977
- Abnormalities in reproductive function associated with the destruction of the suprachiasmatic nuclei in female ratsProceedings of the Royal Society of London. B. Biological Sciences, 1977
- The ‘suprachiasmatic syndrome’: endocrine and behavioural abnormalities following lesions of the suprachiasmatic nuclei in the female ratProceedings of the Royal Society of London. B. Biological Sciences, 1977
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1Journal of Neurochemistry, 1977
- The development of the isthmo‐optic tract in the chick, with special reference to the occurrence and correction of developmental errors in the location and connections of isthmo‐optic neuronsJournal of Comparative Neurology, 1976
- Nucleus Suprachiasmaticus: The Biological Clock in the Hamster?Science, 1976
- Prenatal development of central optic pathways in albino ratsJournal of Comparative Neurology, 1976
- An autoradiographic study of the efferent connections of the ventral lateral geniculate nucleus in the albino rat and the catJournal of Comparative Neurology, 1974
- An autoradiographic study of the time of final division of neurons in rat hypothalamic nucleiJournal of Comparative Neurology, 1972