Biased VH family usage in primary gastric B cell lymphoma of mucosa‐associated lymphoid tissue‐type and the selected Vβ expression of T cells infiltrating into the lymphoma cells

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Abstract
Seven cases of primary gastric low‐grade B cell lymphoma of mucosa‐assoclated lymphoid tissue (MALT) type, two cases of high‐grade B cell lymphoma with a low‐grade component and three cases of pure high‐grade lymphoma were selected for the current study. The Ig VH gene use of lymphoma cells and the Vβ repertoires of infiltrating T cells were Investigated. The VH gene analysis showed multiple VH family usage In 12 cases, but the MALT‐type lymphoma cell usage was found to be biased for the families that have a low number of VH genes (VHIV and V). Another analysis of lymphoma‐lnfiltrating T cells showed restricted expressions of the Vβ repertoire in all seven low‐grade cases and three high‐grade cases. In those 10 cases, a considerable number of CD4‐postttve T cells Infiltrated Into lymphoma cells and RAG‐1 was also prominently expressed. Based on these findings, It was thus assumed that the normal counterpart of gastric B cell lymphoma of MALT type is different from the conventional B cell lymphoma, and the restricted expression of Vβ repertoires Is therefore considered to be a characteristic finding in low‐grade B cell lymphomas of MALT type as well as in a proportion of high‐grade lymphomas (the so called ‘high‐grade lymphoma of MALT type’).