A Big Study Yields Big Questions

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Abstract
It seems that death and taxes are not the only sure things in life anymore. Now, all adults in late middle age must also confront a complex individualized calculation of the risks and benefits of long-term pharmacologic manipulation of the sex hormones.Women and their doctors learned this lesson last summer, when a large study of postmenopausal estrogen and progesterone supplementation was stopped prematurely, with the finding that the hormones relieved menopausal symptoms and lowered the risks of hip fractures and colon cancer but did so at the price of increased risks of myocardial infarction, stroke, and breast cancer.Now . . .

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