Protonated polynucleotide structures. 18. Interaction of oligocytidylates with poly(G)
- 1 January 1976
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 3 (1) , 205-218
- https://doi.org/10.1093/nar/3.1.205
Abstract
The faculty for and degree of oligo(C)-poly(G) interaction is described as an essentially chain length - sensitive phenomenon. At neutral pH under suitable experimental conditions, oligocytidylates of chain length greater than four associate with poly(G) to form double-stranded structures, as does poly(C). The extent of complex formation increases with degree of polymerization. The complex at acid pH is shown to be triple-stranded, of stoicheometry 2C/1G. The observation of a 2G/1C artifact is discussed.Keywords
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