Acetylenics. 2. Synthesis and pharmacology of certain N,N-dialkyl-3-phenylpropyn-2-amines and some analogs with tryptamine-like behavioral effects in mice

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Abstract
A number of N,N-dialkyl-3-phenylpropyn-2-amines were prepared and tested for their biological action. Certain analogs show tryptamine-like behavioral effects in mice. The tryptamine-like activity of these compounds appears to be controlled by their lipophilicity. These compounds show only weak inhibition of rat liver monoamine oxidase. Although these compounds exhibit tryptamine-like action, experiments seem to indicate that there is no interaction with the tryptamine receptors.