Effect of the antidepressant drug-Stelazine on lymphocyte capping
- 1 October 1980
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 4 (10) , 947-952
- https://doi.org/10.1016/0309-1651(80)90197-6
Abstract
The antidepressant agent, Stelazine (trifluoroperazine dihydrochloride), is known to cause inactivation of the calcium-binding protein, calmodulin. We report here that this drug in the concentration range of 5 x 10(-5) M to 10(-6) M causes remarkable inhibitory effets on ligand-induced T-lymphocyte receptor capping. The possible involvement of calmodulin in the regulation of lymphocyte surface receptor movement is therefore implicated.Keywords
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