TWO UNUSUAL CASES OF FAMILIAL MONGOLISM

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Abstract
Two families are reported in which 8 mongoloid children and no normal children were born to 2 different mothers. In Family 1 there were 5 raongoloid boys and 1 miscarriage. Cytogenetic studies showed that the father was a carrier having only 45 chromosomes with 2 members missing in the G group and an extra metacentric member similar to a chromosome of the F group. Three children were examined and were found to have 46 chromosomes, with 1 member missing in the G group and an extra small metacentric believed to have originated from the translocation of 2 chromosomes of pair 21. In Family n, 3 mongoloid boys were born in succession, all 3 of them having 47 chromosomes with trisomy of a short acrocentric and the parents were cytologically normal.